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XPNPEP2

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XPNPEP2
Identifiers
AliasesXPNPEP2, AEACEI, APP2, X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound, X-prolyl aminopeptidase 2
External IDsOMIM: 300145; MGI: 2180001; HomoloGene: 37766; GeneCards: XPNPEP2; OMA:XPNPEP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003399

NM_001289729
NM_133213

RefSeq (protein)

NP_003390

NP_001276658
NP_573476

Location (UCSC)Chr X: 129.74 – 129.77 MbChr X: 47.2 – 47.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Xaa-Pro aminopeptidase 2 is an enzyme that in humans is encoded by the XPNPEP2 gene.[5][6][7]

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes.[7]


References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122121Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037005Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Venema RC, Ju H, Zou R, Venema VJ, Ryan JW (Dec 1997). "Cloning and tissue distribution of human membrane-bound aminopeptidase P". Biochim Biophys Acta. 1354 (1): 45–8. doi:10.1016/s0167-4781(97)00126-7. PMID 9375790.
  6. ^ Sprinkle TJ, Stone AA, Venema RC, Denslow ND, Caldwell C, Ryan JW (Apr 1999). "Assignment of the membrane-bound human aminopeptidase P gene (XPNPEP2) to chromosome Xq25". Genomics. 50 (1): 114–6. doi:10.1006/geno.1998.5302. PMID 9628831.
  7. ^ a b "Entrez Gene: XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound".

Further reading

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