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ZFYVE27

From Wikipedia, the free encyclopedia
ZFYVE27
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZFYVE27, PROTRUDIN, SPG33, zinc finger FYVE-type containing 27
External IDsOMIM: 610243; MGI: 1919602; HomoloGene: 16939; GeneCards: ZFYVE27; OMA:ZFYVE27 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164531
NM_177319

RefSeq (protein)

NP_001158003
NP_796293

Location (UCSC)Chr 10: 97.74 – 97.76 MbChr 19: 42.15 – 42.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger, FYVE domain containing 27 is a protein that in humans is encoded by the ZFYVE27 gene.[5]

Function

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This gene encodes a protein with several Transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote Neurite formation. A mutation in this gene has been reported to be associated with Hereditary spastic paraplegia, however the Pathogenicity of the mutation, which may simply represent a Polymorphism (biology), is unclear. [provided by RefSeq, Mar 2010].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155256Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018820Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Zinc finger, FYVE domain containing 27".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.