Gaia Pigino

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Gaia Pigino
NationalityItalian
Alma materUniversity of Siena (Diploma, PhD)
Awards
Scientific career
Fields
Institutions
Academic advisors
  • Fabio Bernini
  • Claudio Leonzio
  • Pietro Lupetti
  • Takashi Ishikawa
WebsitePigino Lab

Gaia Pigino is the Associate Head of the Structural Biology Research Center[1] and Research Group Leader of the Pigino Group[2] at the Human Technopole in Milan, Italy.[3]

Education[edit]

Pigino studied Natural Science at the University of Siena in Italy, finishing with a Diploma in 2002. From 2003 to 2007, she earned her Ph.D., working in the Department of Evolutionary Biology at the University of Siena, supervised by Prof Fabio Bernini and Prof Claudio Leonzio.[4]

Career and research[edit]

From 2007 to 2009, Pigino was employed at the Laboratory of Cryotechniques for Electron Microscopy in the Department of Evolutionary Biology at the University of Siena, under the guidance of Prof. Pietro Lupetti, while pursuing her postgraduate studies. Subsequently, Pigino worked with Prof. Takashi Ishikawa at the ETH Zurich from 2009 to 2011 and then at the Paul Scherrer Institute from 2010 to 2012.[5][6][7][8]

From 2012 to 2021, Gaia Pigino was a Research Group Leader at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany.[9][10][11]

Since 2021, Pigino has been the Associate Head of the Structural Biology Research Center and Research Group Leader of the Pigino Group at the Human Technopole in Milan, Italy.[12][13][14]

Her research group operates at the intersection of structural and molecular cell biology, utilizing the most current methodologies from both areas to investigate the structure and dynamics of molecular machines that participate in the assembly and function of motile and primary cilia. Their overarching objective is to comprehend the fundamental molecular mechanisms of ciliary functions, as well as their malfunctions in ciliopathies.

Gaia Pigino is an internationally well-known biologist. Hence, she is frequently invited to workshops,[15][16] seminars[17] and conferences[18][19][20][21] in the field.

Awards and honours[edit]

References[edit]

  1. ^ "Structural Biology Website @ Humantechnopole".
  2. ^ "Pigino Group Website @ Humantechnopole".
  3. ^ "Gaia Pigino Profile @ Humantechnopole".
  4. ^ Pigino, G.; Migliorini, M.; Paccagnini, E.; Bernini, F.; Leonzio, C. (2005). "Fine structure of the midgut and Malpighian papillae in Campodea (Monocampa) quilisi Silvestri, 1932 (Hexapoda, Diplura) with special reference to the metal composition and physiological significance of midgut intracellular electron-dense granules". Tissue and Cell. 37 (3): 223–232. doi:10.1016/j.tice.2005.02.001. PMID 15936358.
  5. ^ https://rupress.org/jcb/article/187/1/135/35530/Electron-tomographic-analysis-of-intraflagellar
  6. ^ https://rupress.org/jcb/article/195/4/673/36643/Cryoelectron-tomography-of-radial-spokes-in-cilia
  7. ^ Pigino, Gaia; Ishikawa, Takashi (2012). "Axonemal radial spokes". Bioarchitecture. 2 (2): 50–58. doi:10.4161/bioa.20394. PMC 3383722. PMID 22754630.
  8. ^ Pigino, Gaia; Maheshwari, Aditi; Bui, Khanh Huy; Shingyoji, Chikako; Kamimura, Shinji; Ishikawa, Takashi (2012). "Comparative structural analysis of eukaryotic flagella and cilia from Chlamydomonas, Tetrahymena, and sea urchins". Journal of Structural Biology. 178 (2): 199–206. doi:10.1016/j.jsb.2012.02.012. PMID 22406282.
  9. ^ Stepanek, Ludek; Pigino, Gaia (2016). "Microtubule doublets are double-track railways for intraflagellar transport trains". Science. 352 (6286): 721–724. Bibcode:2016Sci...352..721S. doi:10.1126/science.aaf4594. PMID 27151870. S2CID 206648246.
  10. ^ Jordan, Mareike A.; Diener, Dennis R.; Stepanek, Ludek; Pigino, Gaia (2018). "The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia". Nature Cell Biology. 20 (11): 1250–1255. doi:10.1038/s41556-018-0213-1. PMID 30323187. S2CID 53024569.
  11. ^ Kiesel, Petra; Alvarez Viar, Gonzalo; Tsoy, Nikolai; Maraspini, Riccardo; Gorilak, Peter; Varga, Vladimir; Honigmann, Alf; Pigino, Gaia (2020). "The molecular structure of mammalian primary cilia revealed by cryo-electron tomography". Nature Structural & Molecular Biology. 27 (12): 1115–1124. doi:10.1038/s41594-020-0507-4. PMC 7610599. PMID 32989303.
  12. ^ https://www.cell.com/current-biology/fulltext/S0960-9822(21)00454-1
  13. ^ Van Den Hoek, Hugo; Klena, Nikolai; Jordan, Mareike A.; Alvarez Viar, Gonzalo; Righetto, Ricardo D.; Schaffer, Miroslava; Erdmann, Philipp S.; Wan, William; Geimer, Stefan; Plitzko, Jürgen M.; Baumeister, Wolfgang; Pigino, Gaia; Hamel, Virginie; Guichard, Paul; Engel, Benjamin D. (2022). "In situ architecture of the ciliary base reveals the stepwise assembly of intraflagellar transport trains". Science. 377 (6605): 543–548. Bibcode:2022Sci...377..543V. doi:10.1126/science.abm6704. PMID 35901159. S2CID 251159956.
  14. ^ Lacey, Samuel E.; Foster, Helen E.; Pigino, Gaia (2023). "The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains". Nature Structural & Molecular Biology. 30 (5): 584–593. doi:10.1038/s41594-022-00905-5. PMC 10191852. PMID 36593313.
  15. ^ "The Biophysical Society > Meetings & Events > Annual Meeting > 2024 Annual Meeting > Program > Scientific Sessions > Workshops".
  16. ^ "In situ Structural Biology: From Cryo-EM to Integrative Modelling – Virtual – Course and Conference Office".
  17. ^ "CSSB Seminar Series - GAIA PIGINO".
  18. ^ "Microtubules: From atoms to complex systems – Course and Conference Office".
  19. ^ "Enabling imaging across scales – Course and Conference Office".
  20. ^ "HOME - Cryo-electron Tomography".
  21. ^ "2024 Three Dimensional Electron Microscopy Conference GRC".
  22. ^ https://journals.biologists.com/jcs/article/130/6/1019/56694/Cell-scientist-to-watch-Gaia-Pigino
  23. ^ "Award for exceptional contributions to cell biology". 17 December 2018.
  24. ^ "Self-organization of the cilium: The role of the tubulin code | CiliaTubulinCode Project | Fact Sheet | H2020".
  25. ^ https://erc.europa.eu/sites/default/files/document/file/erc_2018_cog_results_ls.pdf
  26. ^ "Funding for outstanding Research on Cilium and Retina". 29 November 2018.
  27. ^ "Find people in the EMBO Communities".
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