Amyloid-beta precursor protein secretase
This article needs additional citations for verification. (June 2024) |
![](http://upload.wikimedia.org/wikipedia/commons/thumb/c/c6/APP_processing.png/300px-APP_processing.png)
Secretases are enzymes that "snip" pieces off a longer protein that is embedded in the cell membrane.
Among other roles in the cell, secretases act on the amyloid-beta precursor protein (APP) to cleave the protein into three fragments.[citation needed] Sequential cleavage by beta-secretase 1 (BACE) and gamma-secretase (γ-secretase) produces the amyloid-beta peptide fragment that aggregates into clumps called amyloid plaques in the brains affected by Alzheimer's disease.[1] If alpha-secretase (α-secretase) acts on APP first instead of BACE, no amyloid beta is formed because α-secretase recognizes a target protein sequence closer to the cell surface than BACE. The non-pathogenic middle fragment formed by an α/γ cleavage sequence is called P3.[citation needed]
Structure[edit]
The structure of the three secretases varies widely.
- The α-secretase gene has not been conclusively identified but is believed to be a metalloproteinase.
- BACE is a transmembrane protein with an extracellular aspartic acid protease domain.
- γ-secretase is actually a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. Presenilin is believed to harbor the protease domain and represents an important example of an uncommon type of protease that cleaves targets within the cell membrane.
Function[edit]
Besides their involvement in the pathogenesis of Alzheimer's, these proteins also have other functional roles in the cell.
γ-secretase plays a critical role in developmental signalling by the transmembrane receptor Notch, freeing the cytoplasmic tail of Notch to travel to the cell nucleus to act as a transcription factor.
Although BACE cleaves the extracellular domains of several transmembrane proteins, its physiological function remains unknown.
References[edit]
- ^ Bhatia, S. (12 August 2023). "Scaffold Morphing and In Silico Design of Potential BACE-1 (β-Secretase) Inhibitors: A Hope for a Newer Dawn in Anti-Alzheimer Therapeutics". Molecules. 28 (16). Basel, Switzerland. doi:10.3390/molecules28166032.
{{cite journal}}
: CS1 maint: unflagged free DOI (link)
External links[edit]
- Secretase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)