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CEP120

From Wikipedia, the free encyclopedia
CEP120
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCEP120, CCDC100, SRTD13, centrosomal protein 120, JBTS31
External IDsOMIM: 613446; MGI: 2147298; HomoloGene: 27415; GeneCards: CEP120; OMA:CEP120 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166226
NM_153223

NM_178686

RefSeq (protein)

NP_848801

Location (UCSC)Chr 5: 123.34 – 123.42 MbChr 18: 53.81 – 53.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosomal protein of 120 kDa (Cep120), also known as coiled-coil domain-containing protein 100, is a protein that in humans is encoded by the CEP120 gene.[5][6]

Function

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This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168944Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048799Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: centrosomal protein 120kDa".
  6. ^ Xie Z, Moy LY, Sanada K, Zhou Y, Buchman JJ, Tsai LH (October 2007). "Cep120 and TACCs Control Interkinetic Nuclear Migration and the Neural Progenitor Pool". Neuron. 56 (1): 79–93. doi:10.1016/j.neuron.2007.08.026. PMC 2642594. PMID 17920017.
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  • Human CEP120 genome location and CEP120 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 120 kDa (CEP120)

Further reading

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