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Draft:Itamar Harel

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Itamar Harel
איתמר הראל
NationalityIsraeli
SpouseGuy Katz
Scientific career
FieldsExperimental biology of vertebrate aging and age-related diseases
InstitutionsThe Alexander Silberman Institute of Life Sciences, the Hebrew University of Jerusalem
Websitehttps://harel-lab.com/

Itamar Harel is an Israeli scientist, faculty member in the Department of Genetics at the Alexander Silberman Institute of Life sciences, the Hebrew University of Jerusalem, Israel. His research focusses on vertebrate aging and age-related diseases.

Research[edit]

Harel is a geneticist known for his work on aging and related diseases, as reviewed in[1][2][3][4]. Harel's research focuses on understanding the mechanisms of aging and longevity, with a particular interest in using the emerging African turquoise killifish (Nothobranchius furzeri) model to study these processes.[5][6][7][8] His work aims to uncover the biological pathways that influence aging in order to develop potential interventions to promote healthy aging.

Harel developed a genetic platform in the naturally short-lived turquoise killifish[9][10], which lives only twice as long as Drosophila. Using this vertebrate model he explored protein aggregation with age, revealing naturally occurring prion-like behaviors that propose an alternative mechanism for damage propagation during aging.[11][12]

He then explored how aging is scaled between species, what mediates its sexual dimorphism, and why longevity is proportional to other species-specific traits such as age at maturity. In a series of studies, the Harel lab revealed additional mechanisms that regulate vertebrate longevity. They identified how reproduction might impact vertebrate aging by demonstrating that the germline itself can regulate longevity and stress resistance in a sex-specific manner.[7][13] Additionally, the Harel lab discovered another vertebrate longevity mechanism linked to energy homeostasis via the AMP-activated protein kinase (AMPK) pathway.[8][14]

Research in Harel's laboratory also focuses on developing genetic tools, including lineage tracing, modeling of sporadic age-related cancers, and precise control of pituitary hormones in-vivo.[15][16][17]

Awards & Honors[edit]

  • 2024 - Krill Prize for Excellence in Scientific Research by the Wolf Foundation.[18]
  • 2024 - Elected member, the Young Academy of Europe (YAE).[19]
  • 2023 - Invited to join the Pamela and Paul Austin Research Centre on Aging.[20]
  • 2018 - Invited to join the Zuckerman STEM leadership program.[21]
  • 2017 - Member of the International Zebrafish Society (2017).[22]

Selected Publications[edit]

  1. Moses, E. et al. The killifish germline regulates longevity and somatic repair in a sex-specific manner. Nature Aging (2024) DOI: 10.1038/s43587-024-00632-0
  2. Harel, I. et al. Identification of protein aggregates in the aging vertebrate brain with prion-like and phase-separation properties. Cell Reports (2024) DOI: 10.1016/j.celrep.2023.112787
  3. Chen, Y. R. et al. Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate. Developmental Cell (2024) DOI:10.1016/j.devcel.2024.04.014.
  4. Moses, E., Franek, R. & Harel, I. A scalable and tunable platform for functional interrogation of peptide hormones in fish. Elife (2023) DOI: 10.7554/eLife.85960
  5. Astre, G. et al. Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate. Developmental Cell (2023) DOI: 10.1016/j.devcel.2023.05.015
  6. Harel, I. The turquoise killifish. Nature Methods (2022) doi:10.1038/s41592-022-01631-y.
  7. Harel, I. et al. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. Cell (2015) DOI:10.1016/j.cell.2015.01.038.

External Links[edit]

The Harel Lab - Experimental biology of vertebrate aging and age-related diseases[23]

References[edit]

  1. ^ Marx, Vivien (January 2024). "Aging research comes of age". Nature Methods. 21 (1): 11–15. doi:10.1038/s41592-023-02140-2. ISSN 1548-7105. PMID 38167657.
  2. ^ Dance, Amber (July 2016). "Live fast, die young". Nature. 535 (7612): 453–455. Bibcode:2016Natur.535..453D. doi:10.1038/535453a. ISSN 1476-4687. PMID 27443744.
  3. ^ Singh, Param Priya; Demmitt, Brittany A.; Nath, Ravi D.; Brunet, Anne (March 2019). "The Genetics of Aging: A Vertebrate Perspective". Cell. 177 (1): 200–220. doi:10.1016/j.cell.2019.02.038. PMC 7592626. PMID 30901541.
  4. ^ Wang, Adrienne M.; Promislow, Daniel E.L.; Kaeberlein, Matt (February 2015). "Fertile Waters for Aging Research". Cell. 160 (5): 814–815. doi:10.1016/j.cell.2015.02.026. PMID 25723160.
  5. ^ Harel, Itamar (October 2022). "The turquoise killifish". Nature Methods. 19 (10): 1150–1151. doi:10.1038/s41592-022-01631-y. ISSN 1548-7091. PMID 36203025.
  6. ^ Zimmer, Carl (27 February 2015). "In Short-Lived Fish, Secrets to Aging". The New York Times.
  7. ^ a b "How germline regulation, sex differences impact the lifespan of male, female vertebrates". 15 May 2024.
  8. ^ a b "AMP biosynthesis key to longevity and metabolic health in vertebrates".
  9. ^ Harel, Itamar; Benayoun, Bérénice A.; Machado, Ben; Singh, Param Priya; Hu, Chi-Kuo; Pech, Matthew F.; Valenzano, Dario Riccardo; Zhang, Elisa; Sharp, Sabrina C.; Artandi, Steven E.; Brunet, Anne (February 2015). "A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate". Cell. 160 (5): 1013–1026. doi:10.1016/j.cell.2015.01.038. PMC 4344913. PMID 25684364.
  10. ^ Harel, Itamar; Valenzano, Dario Riccardo; Brunet, Anne (October 2016). "Efficient genome engineering approaches for the short-lived African turquoise killifish". Nature Protocols. 11 (10): 2010–2028. doi:10.1038/nprot.2016.103. ISSN 1750-2799. PMID 27658015.
  11. ^ Harel, Itamar; Chen, Yiwen R.; Ziv, Inbal; Singh, Param Priya; Heinzer, Daniel; Navarro Negredo, Paloma; Goshtchevsky, Uri; Wang, Wei; Astre, Gwendoline; Moses, Eitan; McKay, Andrew; Machado, Ben E.; Hebestreit, Katja; Yin, Sifei; Sánchez Alvarado, Alejandro; Jarosz, Daniel F.; Brunet, Anne (May 2024). "Identification of protein aggregates in the aging vertebrate brain with prion-like and phase-separation properties". Cell Reports: 112787. doi:10.1016/j.celrep.2023.112787. PMID 38810650.
  12. ^ Chen, Yiwen R.; Harel, Itamar; Singh, Param Priya; Ziv, Inbal; Moses, Eitan; Goshtchevsky, Uri; Machado, Ben E.; Brunet, Anne; Jarosz, Daniel F. (May 2024). "Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate". Developmental Cell. doi:10.1016/j.devcel.2024.04.014. PMID 38810654.
  13. ^ Moses, Eitan; Atlan, Tehila; Sun, Xue; Franěk, Roman; Siddiqui, Atif; Marinov, Georgi K.; Shifman, Sagiv; Zucker, David M.; Oron-Gottesman, Adi; Greenleaf, William J.; Cohen, Ehud; Ram, Oren; Harel, Itamar (2024-05-15). "The killifish germline regulates longevity and somatic repair in a sex-specific manner". Nature Aging: 1–23. doi:10.1038/s43587-024-00632-0. ISSN 2662-8465. PMID 38750187.
  14. ^ Astre, Gwendoline; Atlan, Tehila; Goshtchevsky, Uri; Oron-Gottesman, Adi; Smirnov, Margarita; Shapira, Kobi; Velan, Ariel; Deelen, Joris; Levy, Tomer; Levanon, Erez Y.; Harel, Itamar (August 2023). "Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate". Developmental Cell. 58 (15): 1350–1364.e10. doi:10.1016/j.devcel.2023.05.015. PMID 37321215.
  15. ^ Rozenberg, Itai; Moses, Eitan; Harel, Itamar (1 February 2023). "CRISPR–Cas9 Genome Editing in Nothobranchius furzeri for Gene Knockout and Knock-In". Cold Spring Harbor Protocols. 2023 (2): 90–99. doi:10.1101/pdb.prot107742. ISSN 1940-3402. PMID 36223984.
  16. ^ Moses, Eitan; Franek, Roman; Harel, Itamar (2023-10-24). "A scalable and tunable platform for functional interrogation of peptide hormones in fish". eLife. 12. doi:10.7554/eLife.85960. ISSN 2050-084X. PMC 10597582. PMID 37872843.
  17. ^ "A new versatile tool for studying fish hormones - may transform fish farming, Eurokalert".
  18. ^ "Itamar Harel, Krill Prize 2024". 26 May 2024.
  19. ^ "Young Academy of Europe, members".
  20. ^ "The Pamela and Paul Austin Research Centre on Aging".
  21. ^ "Zuckerman STEM leadership program".
  22. ^ "The International Zebrafish Society (IZFS)".
  23. ^ "The Harel Lab - Experimental biology of vertebrate aging and age-related diseases".
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