Draft:Jan Liphardt
Submission declined on 4 February 2024 by Ldm1954 (talk).
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Submission declined on 3 January 2024 by Ldm1954 (talk). This draft's references do not show that the subject qualifies for a Wikipedia article. In summary, the draft needs to Declined by Ldm1954 7 months ago.
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Submission declined on 28 December 2023 by Tagishsimon (talk). This submission's references do not show that the subject qualifies for a Wikipedia article—that is, they do not show significant coverage (not just passing mentions) about the subject in published, reliable, secondary sources that are independent of the subject (see the guidelines on the notability of people). Before any resubmission, additional references meeting these criteria should be added (see technical help and learn about mistakes to avoid when addressing this issue). If no additional references exist, the subject is not suitable for Wikipedia. Declined by Tagishsimon 8 months ago. | ![]() |
Submission declined on 28 December 2023 by Sungodtemple (talk). The content of this submission includes material that does not meet Wikipedia's minimum standard for inline citations. Please cite your sources using footnotes. For instructions on how to do this, please see Referencing for beginners. Thank you. Declined by Sungodtemple 8 months ago. | ![]() |
Comment: Just adding a few references does not convince. With an h-factor of 40 he is making progress, but he is not there yet. 15,000 cites is not notable. Please don't keep submitting without resolving some of the other issues such as low relevance "awards". Also, if you want to claim his use as a staple in texts you must give page numbers. The mention will need to be pages, not a single aside. Ldm1954 (talk) 03:39, 4 February 2024 (UTC)
Comment: He would need to receive significant awards to qualify as a notable academic WP:NPROF. Neither the NCI nor the Biden qualify as major accomplishments. In addition, you need to have independent sources, not just his papers to establish notability. Ldm1954 (talk) 23:52, 3 January 2024 (UTC)
Comment: 1. References are very poor, do not pass WP:GNG. No obvious sign that he passes WP:NACADEMIC. Name dropping " published with Paul Alivisatos[1], currently the President of University of Chicago, and with Nobel Laureates Steven Ch" unwelcome / unhelpful. Tagishsimon (talk) 07:17, 28 December 2023 (UTC)
![]() | The topic of this draft may not meet Wikipedia's notability guideline for academics. (March 2024) |
Jan Liphardt | |
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Born | 1972 (age 51–52) |
Citizenship | Germany |
Awards | |
Academic background | |
Education | Biophysics |
Alma mater | Cambridge University University of California, Berkeley |
Academic advisors | Carlos Bustamante, Ignacio Tinoco Jr. |
Academic work | |
Discipline | Biological engineering Biophysics Microscopy Cell biology |
Institutions | University of California, Berkeley Stanford University |
Notable students | Aleksandra Radenovic |
Main interests | Single molecule biophysics Solid State Nanopores Optical tweezers Super-resolution microscopy |
Website | https://liphardtlab.stanford.edu |
Jan Liphardt (born 1972 in Germany) is a German biophysicist. His research primarily focuses on single molecule biophysics. As a postdoctoral fellow in the labs of Carlos Bustamante and Ignacio Tinoco Jr. in the physics department at University of California, Berkeley, he developed technologies that allowed single RNA molecules to grabbed and mechanically unfolded.[1] Subsequent work includes the development of "Plasmon Rulers"[2] (with Paul Alivisatos), the use of super-resolution imaging to understand the organization of microbial biofilms[3] (with Steven Chu), and the use of photo activation localization microscopy to characterize the organization of single transmembrane proteins[4] (with Eric Betzig). He is an associate professor of bioengineering at Stanford University. His research has been cited more than 15,000 times.[5]
Mechanical Manipulation of Single Nucleic Acids
[edit]In the original work performed in 2001,[1] single RNA hairpins were attached to long RNA/DNA 'handles' which were chemically coupled to beads held by optical tweezers. The RNA/DNA handles allow nanometer scale movements (and piconewton range forces) to be applied and measured. This basic tool geometry has been cited by more than 1100 papers covering RNA structure/function (reviewed in[6][7][8]), studies of thermodynamics of small perturbed systems (reviewed in[9][10]), and studies of molecular machines that act on RNA, such as RNA helicases[11] (reviewed in[12]). The original work (and followup studies) are used in life sciences and nanotechnology textbooks to illustrate the energetics and kinetics of nucleic acid folding.[13][14][15]
NCI PS-OC Program
[edit]In 2009, Liphardt became the principal investigator of one of 12 national physical science oncology centers,[16][17] which were intended to bring physical scientists to cancer research.[18][19]
Biden Cancer Moonshot
[edit]In 2016, as part of the Beau Biden Cancer Moonshot, he led a team of scientists and volunteers from a Bay Area social network[20] to build a system for cancer patients to share their healthcare data with teachers, researchers, and journalists.[21]
References
[edit]- ^ a b Liphardt J, Onoa B, Smith SB, Tinoco I, Bustamante C (2001). "Reversible unfolding of single RNA molecules by mechanical force". Science. 292 (5517): 733–7. Bibcode:2001Sci...292..733L. doi:10.1126/science.1058498. PMID 11326101. S2CID 43054051.
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: CS1 maint: multiple names: authors list (link) - ^ Sönnichsen C, Reinhard BM, Liphardt J, Alivisatos AP (2005). "A molecular ruler based on plasmon coupling of single gold and silver nanoparticles". Nat Biotechnol. 23 (6): 741–5. doi:10.1038/nbt1100. PMID 15908940. S2CID 7032868.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ Berk V, Fong JC, Dempsey GT, Develioglu ON, Zhuang X, Liphardt J; et al. (2012). "Molecular architecture and assembly principles of Vibrio cholerae biofilms". Science. 337 (6091): 236–9. Bibcode:2012Sci...337..236B. doi:10.1126/science.1222981. PMC 3513368. PMID 22798614.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ Greenfield D, McEvoy AL, Shroff H, Crooks GE, Wingreen NS, Betzig E; et al. (2009). "Self-organization of the Escherichia coli chemotaxis network imaged with super-resolution light microscopy". PLOS Biol. 7 (6): e1000137. doi:10.1371/journal.pbio.1000137. PMC 2691949. PMID 19547746.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ "Liphardt Citations". Google Scholar. Retrieved 2023-12-27.
- ^ Bustamante CJ, Chemla YR, Liu S, Wang MD (2021). "Optical tweezers in single-molecule biophysics". Nat Rev Methods Primers. 1. doi:10.1038/s43586-021-00021-6. PMC 8629167. PMID 34849486.
- ^ Tinoco I, Chen G, Qu X (November 2010). "RNA reactions one molecule at a time". Cold Spring Harb Perspect Biol. 2 (11): a003624. doi:10.1101/cshperspect.a003624. PMC 2964187. PMID 20739416.
- ^ Li PT, Vieregg J, Tinoco I (2008). "How RNA unfolds and refolds". Annu Rev Biochem. 77: 77–100. doi:10.1146/annurev.biochem.77.061206.174353. PMID 18518818.
- ^ Rissone P, Ritort F (July 2022). "Nucleic Acid Thermodynamics Derived from Mechanical Unzipping Experiments". Life (Basel). 12 (7): 1089. Bibcode:2022Life...12.1089R. doi:10.3390/life12071089. PMC 9320087. PMID 35888177.
- ^ Ritort F (August 2006). "Single-molecule experiments in biological physics: methods and applications". J Phys Condens Matter. 18 (32): R531–83. arXiv:cond-mat/0609378. doi:10.1088/0953-8984/18/32/R01. PMID 21690856.
- ^ Dumont S, Cheng W, Serebrov V, Beran RK, Tinoco I, Pyle AM, Bustamante C (January 2006). "RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP". Nature. 439 (7072): 105–8. Bibcode:2006Natur.439..105D. doi:10.1038/nature04331. PMC 1560093. PMID 16397502.
- ^ Ritchie DB, Woodside MT (October 2015). "Probing the structural dynamics of proteins and nucleic acids with optical tweezers". Curr Opin Struct Biol. 34: 43–51. doi:10.1016/j.sbi.2015.06.006. PMC 7126019. PMID 26189090.
- ^ Nelson, Philip; Goodsell, David S. (2014). Biological physics: energy, information, life; with new art by David Goodsell. New York, NY: Freeman. ISBN 978-0-7167-9897-2.
- ^ Walter, Nils; Woodson, Sarah A.; Batey, Robert T. (2008-11-18). Non-Protein Coding RNAs. Berlin: Springer Science & Business Media. ISBN 978-3-540-70840-7.
- ^ Bai, Y.L.; Zheng, Q.S.; Wei, Y.G. (2007-04-05). IUTAM Symposium on Mechanical Behavior and Micro-Mechanics of Nanostructured Materials. Dordrecht London: Springer Science & Business Media. ISBN 978-1-4020-5624-6.
- ^ "UCSF Scientists Help Guide Cancer Research to a Melding of Physics & Biology". UCSF. November 4, 2009. Retrieved December 28, 2023.
- ^ "Cal, UCSF scientists form cancer research unit". SFGATE. October 27, 2009. Retrieved December 28, 2023.
- ^ Yarris, Lynn (March 11, 2009). "Berkeley Scientists Find New Way to Get Physical in the Fight Against Cancer". Lawrence Berkeley National Lab. Retrieved December 28, 2023.
- ^ Barker, Anna (March 23, 2010). "National Cancer Institute Research: Today's Progress; Tomorrow's Challenges" (PDF). NCI. Retrieved December 28, 2023.
- ^ "FACT SHEET: At Cancer Moonshot Summit, Vice President Biden Announces New Actions to Accelerate Progress Toward Ending Cancer As We Know It". The White House, Office of the Press Secretary. June 28, 2016. Retrieved December 28, 2023.
- ^ Suarez, Ray (January 12, 2017). "The 'Cancer Moonshot,' One Year After Takeoff". KQED/NPR. Retrieved December 28, 2023.
External links
[edit]- Website of the Liphardt Lab
- Jan Liphardt publications indexed by Google Scholar
Category:21st-century German scientists
Category:Bioengineers
Category:1972 births
Category:Living people
- meet any of the eight academic-specific criteria
- or cite multiple reliable, secondary sources independent of the subject, which cover the subject in some depth
Make sure your draft meets one of the criteria above before resubmitting. Learn about mistakes to avoid when addressing this issue. If the subject does not meet any of the criteria, it is not suitable for Wikipedia.