Integrin alpha-1

ITGA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PT6, 1QC5, 1QCY, 2L8S, 4A0Q, 2M32
Identifiers
Aliases	ITGA1, CD49a, VLA1, integrin subunit alpha 1
External IDs	OMIM: 192968; MGI: 96599; HomoloGene: 57137; GeneCards: ITGA1; OMA:ITGA1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	52,959,209 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	115,238,500 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; gastric mucosa; ; right coronary artery; ; stromal cell of endometrium; ; epithelium of colon; ; saphenous vein; ; right lung; ; popliteal artery; ; tibial arteries; ; left coronary artery;
	Top expressed in
	right lung; ; right lung lobe; ; umbilical cord; ; aorta; ; left lung lobe; ; ascending aorta; ; sciatic nerve; ; brown adipose tissue; ; vas deferens; ; decidua;
	More reference expression data
	n/a
Gene ontology
Molecular function	collagen binding; metal ion binding; protein binding; collagen binding involved in cell-matrix adhesion; protein phosphatase binding; signaling receptor binding;
Cellular component	integral component of membrane; perikaryon; integrin alpha1-beta1 complex; membrane; focal adhesion; basal part of cell; plasma membrane; cell surface; integrin complex; acrosomal vesicle; membrane raft; neuron projection; extracellular exosome; external side of plasma membrane;
Biological process	neuron projection morphogenesis; muscle contraction; negative regulation of epidermal growth factor receptor signaling pathway; extracellular matrix organization; vasodilation; neutrophil chemotaxis; positive regulation of neuron apoptotic process; positive regulation of phosphoprotein phosphatase activity; cell adhesion; cell chemotaxis; integrin-mediated signaling pathway; cellular extravasation; cell-matrix adhesion; negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3672
	109700
	ENSG00000213949
	ENSMUSG00000042284
	P56199
	Q3V3R4
	NM_181501
	NM_001033228
	NP_852478
	NP_001028400
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others.^[5]

CD49a has been implicated as a marker of tissue resident memory T cells, where it may be coexpressed with other markers CD103 and CD69.^[6] It has been shown to affect the motility of T cells.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213949 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042284 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gardner H (2014). "Integrin α1β1". I Domain Integrins. Advances in Experimental Medicine and Biology. Vol. 819. pp. 21–39. doi:10.1007/978-94-017-9153-3_2. ISBN 978-94-017-9152-6. PMID 25023165.
^ Reilly EC, Sportiello M, Emo KL, Amitrano AM, Jha R, Kumar AB, et al. (9 September 2021). "CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection". Frontiers in Immunology. 12: 728669. doi:10.3389/fimmu.2021.728669. PMC 8462271. PMID 34566986.
^ Reilly EC, Lambert Emo K, Buckley PM, Reilly NS, Smith I, Chaves FA, et al. (June 2020). "T_RM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection". Proceedings of the National Academy of Sciences of the United States of America. 117 (22): 12306–12314. doi:10.1073/pnas.1915681117. PMC 7275699. PMID 32439709.

Virtanen I, Korhonen M, Kariniemi AL, Gould VE, Laitinen L, Ylänne J (December 1990). "Integrins in human cells and tumors". Cell Differentiation and Development. 32 (3): 215–227. doi:10.1016/0922-3371(90)90034-T. PMID 2099238.
Plenz GA, Deng MC, Robenek H, Völker W (January 2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis". Atherosclerosis. 166 (1): 1–11. doi:10.1016/S0021-9150(01)00766-3. PMID 12482545.
Clover J, Dodds RA, Gowen M (September 1992). "Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture". Journal of Cell Science. 103 ( Pt 1) (1): 267–271. doi:10.1242/jcs.103.1.267. PMID 1429908.
Bodary SC, McLean JW (April 1990). "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line". The Journal of Biological Chemistry. 265 (11): 5938–5941. doi:10.1016/S0021-9258(19)39269-5. PMID 1690718.
Sonnenberg A, Linders CJ, Modderman PW, Damsky CH, Aumailley M, Timpl R (June 1990). "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8". The Journal of Cell Biology. 110 (6): 2145–2155. doi:10.1083/jcb.110.6.2145. PMC 2116116. PMID 1693624.
Belkin VM, Belkin AM, Dol'nikova AE, Tarasova EA, Kotelianskiĭ VE (December 1991). "[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles]". Biokhimiia. 56 (12): 2198–2206. PMID 1807406.
Bank I, Roth D, Book M, Guterman A, Shnirrer I, Block R, et al. (January 1991). "Expression and functions of very late antigen 1 in inflammatory joint diseases". Journal of Clinical Immunology. 11 (1): 29–38. doi:10.1007/BF00918792. PMID 1827128. S2CID 6198792.
Tabibzadeh S (September 1990). "Evidence of T-cell activation and potential cytokine action in human endometrium". The Journal of Clinical Endocrinology and Metabolism. 71 (3): 645–649. doi:10.1210/jcem-71-3-645. PMID 2144294.
Tawil NJ, Houde M, Blacher R, Esch F, Reichardt LF, Turner DC, et al. (July 1990). "Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells". Biochemistry. 29 (27): 6540–6544. doi:10.1021/bi00479a028. PMC 2710132. PMID 2169872.
Belkin VM, Belkin AM, Koteliansky VE (November 1990). "Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development". The Journal of Cell Biology. 111 (5 Pt 1): 2159–2170. doi:10.1083/jcb.111.5.2159. PMC 2116325. PMID 2229189.
MacDonald TT, Horton MA, Choy MY, Richman PI (April 1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine". Journal of Clinical Pathology. 43 (4): 313–315. doi:10.1136/jcp.43.4.313. PMC 502365. PMID 2341567.
Takada Y, Strominger JL, Hemler ME (May 1987). "The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis". Proceedings of the National Academy of Sciences of the United States of America. 84 (10): 3239–3243. Bibcode:1987PNAS...84.3239T. doi:10.1073/pnas.84.10.3239. PMC 304844. PMID 3033641.
Hemler ME, Huang C, Schwarz L (March 1987). "The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit". The Journal of Biological Chemistry. 262 (7): 3300–3309. doi:10.1016/S0021-9258(18)61504-2. PMID 3546305.
Kono Y, Yang S, Letarte M, Roberts EA (December 1995). "Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system". Experimental Cell Research. 221 (2): 478–485. doi:10.1006/excr.1995.1399. PMID 7493648.
Eglinton BA, Roberton DM, Cummins AG (August 1994). "Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk". Immunology and Cell Biology. 72 (4): 306–313. doi:10.1038/icb.1994.46. PMID 7806264. S2CID 25016970.
Salter DM, Godolphin JL, Gourlay MS (April 1995). "Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees". The Journal of Histochemistry and Cytochemistry. 43 (4): 447–457. doi:10.1177/43.4.7897185. PMID 7897185.
Pfaff M, Aumailley M, Specks U, Knolle J, Zerwes HG, Timpl R (May 1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI". Experimental Cell Research. 206 (1): 167–176. doi:10.1006/excr.1993.1134. PMID 8387021.
Briesewitz R, Epstein MR, Marcantonio EE (February 1993). "Expression of native and truncated forms of the human integrin alpha 1 subunit". The Journal of Biological Chemistry. 268 (4): 2989–2996. doi:10.1016/S0021-9258(18)53871-0. PMID 8428973.
Langholz O, Röckel D, Mauch C, Kozlowska E, Bank I, Krieg T, et al. (December 1995). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins". The Journal of Cell Biology. 131 (6 Pt 2): 1903–1915. doi:10.1083/jcb.131.6.1903. PMC 2120685. PMID 8557756.
Gardner H, Kreidberg J, Koteliansky V, Jaenisch R (May 1996). "Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion". Developmental Biology. 175 (2): 301–313. doi:10.1006/dbio.1996.0116. PMID 8626034.

External links

CD49a+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human ITGA1 genome location and ITGA1 gene details page in the UCSC Genome Browser.
ITGA1 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
PDBe-KB provides an overview of all the structure information available in the PDB for Human Integrin alpha-1

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213949 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042284 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Gardner H (2014). "Integrin α1β1". I Domain Integrins. Advances in Experimental Medicine and Biology. Vol. 819. pp. 21–39. doi:10.1007/978-94-017-9153-3_2. ISBN 978-94-017-9152-6. PMID 25023165.

[6] Reilly EC, Sportiello M, Emo KL, Amitrano AM, Jha R, Kumar AB, et al. (9 September 2021). "CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection". Frontiers in Immunology. 12: 728669. doi:10.3389/fimmu.2021.728669. PMC 8462271. PMID 34566986.

[7] Reilly EC, Lambert Emo K, Buckley PM, Reilly NS, Smith I, Chaves FA, et al. (June 2020). "T_RM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection". Proceedings of the National Academy of Sciences of the United States of America. 117 (22): 12306–12314. doi:10.1073/pnas.1915681117. PMC 7275699. PMID 32439709.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

References

Further reading

External links