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User:Mr. Ibrahem/Trifluridine/tipiracil

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Mr. Ibrahem/Trifluridine/tipiracil
Combination of
TrifluridineCytotoxin
TipiracilThymidine phosphorylase inhibitor
Clinical data
Trade namesLonsurf
Other namesTAS-102
AHFS/Drugs.comMonograph
MedlinePlusa615049
License data
Pregnancy
category
  • AU: D
Routes of
administration		By mouth (tablets)
Legal status
Legal status

Trifluridine/tipiracil, sold under the brand name Lonsurf, is a combination medication used to treat metastatic colorectal cancer or gastric cancer, in those in who other treatments have failed.[3] It is taken by mouth.[4]

The most common side effects are low neutrophils, tiredness, nausea, fever, hair loss, and low red blood cells.[3][5] Other serious side effects include diarrhea.[3] Use during pregnancy may harm the baby.[5] It is a combination of trifluridine, a nucleoside analog, and tipiracil, a thymidine phosphorylase blocker.[5][3] Tipiracil prevents breakdown of trifluridine, thus increasing its level.[3]

Trifluridine/tipiracil was approved for medical use in the United States in 2015 and Europe in 2016.[3][5] In the United Kingdom 20 tablets of 20 mg trifluridine cost the NHS £2,000 as of 2021.[4] This amount in the United States costs about 5,000 USD.[6]

References[edit]

  1. ^ "UK Label: Lonsurf - Summary of Product Characteristics". Electronic Medicines Compendium. August 2017. Archived from the original on 11 May 2018. Retrieved 10 May 2018.
  2. ^ "Lonsurf- trifluridine and tipiracil tablet, film coated". DailyMed. 14 January 2020. Archived from the original on 21 October 2020. Retrieved 20 October 2020.
  3. ^ a b c d e f g h "Lonsurf EPAR". European Medicines Agency (EMA). Archived from the original on 21 October 2020. Retrieved 20 October 2020.
  4. ^ a b BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 969. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
  5. ^ a b c d "Trifluridine and Tipiracil Monograph for Professionals". Drugs.com. Archived from the original on 21 September 2021. Retrieved 19 September 2021.
  6. ^ "Lonsurf Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 24 January 2021. Retrieved 19 September 2021.
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