Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 16:39, 9 April 2008 (UTC)
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Proteins without matches (1)
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Redirected Proteins (24)
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Manual Inspection (Page not found) (1)
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Protein Status Grid - Date: 16:39, 9 April 2008 (UTC)
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Vebose Log - Date: 16:39, 9 April 2008 (UTC)
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- INFO: Beginning work on ABCB8... {April 9, 2008 9:27:23 AM PDT}
- REDIRECT: Protein Redirected to: ABCB8 {April 9, 2008 9:27:48 AM PDT}
- CREATED: Created new protein page: ABCB8 {April 9, 2008 9:27:52 AM PDT}
- INFO: Beginning work on ABHD2... {April 9, 2008 9:18:09 AM PDT}
- REDIRECT: Protein Redirected to: ABHD2 {April 9, 2008 9:18:49 AM PDT}
- CREATED: Created new protein page: ABHD2 {April 9, 2008 9:18:56 AM PDT}
- INFO: Beginning work on ADAMTS8... {April 9, 2008 9:18:56 AM PDT}
- REDIRECT: Page directory gave bad page (ADAMTS8). Continuing with search.. Please correct entry: <11095,ADAMTS8>. {April 9, 2008 9:19:11 AM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {April 9, 2008 9:19:17 AM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ADAM metallopeptidase with thrombospondin type 1 motif, 8
| HGNCid = 224
| Symbol = ADAMTS8
| AltSymbols =; ADAM-TS8; FLJ41712; METH2
| OMIM = 605175
| ECnumber =
| Homologene = 5108
| MGIid = 1353468
| Function = {{GNF_GO|id=GO:0004222 |text = metalloendopeptidase activity}}{{GNF_GO|id=GO:0005178 |text = integrin binding}}{{GNF_GO|id=GO:0008201 |text = heparin binding}}{{GNF_GO|id=GO:0008270 |text = zinc ion binding}}{{GNF_GO|id=GO:0009673 |text = low affinity phosphate transmembrane transporter activity}}{{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 11095
| Hs_Ensembl =
| Hs_RefseqProtein = NP_008968
| Hs_RefseqmRNA = NM_007037
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 30806
| Mm_Ensembl = ENSMUSG00000031994
| Mm_RefseqmRNA = XM_993020
| Mm_RefseqProtein = XP_998114
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 30692127
| Mm_GenLoc_end = 30712421
| Mm_Uniprot = Q99JP1
}}
}}
'''ADAM metallopeptidase with thrombospondin type 1 motif, 8''', also known as '''ADAMTS8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11095| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.<ref name="entrez">{{cite web | title = Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11095| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wågsäter D, Björk H, Zhu C, ''et al.'' |title=ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. |journal=Atherosclerosis |volume=196 |issue= 2 |pages= 514-22 |year= 2008 |pmid= 17606262 |doi= 10.1016/j.atherosclerosis.2007.05.018 }}
*{{cite journal | author=Dunn JR, Reed JE, du Plessis DG, ''et al.'' |title=Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours. |journal=Br. J. Cancer |volume=94 |issue= 8 |pages= 1186-93 |year= 2006 |pmid= 16570050 |doi= 10.1038/sj.bjc.6603006 }}
*{{cite journal | author=Porter S, Span PN, Sweep FC, ''et al.'' |title=ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. |journal=Int. J. Cancer |volume=118 |issue= 5 |pages= 1241-7 |year= 2006 |pmid= 16152618 |doi= 10.1002/ijc.21476 }}
*{{cite journal | author=Dunn JR, Panutsopulos D, Shaw MW, ''et al.'' |title=METH-2 silencing and promoter hypermethylation in NSCLC. |journal=Br. J. Cancer |volume=91 |issue= 6 |pages= 1149-54 |year= 2004 |pmid= 15328519 |doi= 10.1038/sj.bjc.6602107 }}
*{{cite journal | author=Collins-Racie LA, Flannery CR, Zeng W, ''et al.'' |title=ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. |journal=Matrix Biol. |volume=23 |issue= 4 |pages= 219-30 |year= 2005 |pmid= 15296936 |doi= 10.1016/j.matbio.2004.05.004 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Georgiadis KE, Hirohata S, Seldin MF, Apte SS |title=ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. |journal=Genomics |volume=62 |issue= 2 |pages= 312-5 |year= 2000 |pmid= 10610729 |doi= 10.1006/geno.1999.6014 }}
*{{cite journal | author=Vázquez F, Hastings G, Ortega MA, ''et al.'' |title=METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23349-57 |year= 1999 |pmid= 10438512 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BLCAP... {April 9, 2008 9:04:47 AM PDT}
- REDIRECT: Protein Redirected to: BLCAP {April 9, 2008 9:05:15 AM PDT}
- CREATED: Created new protein page: BLCAP {April 9, 2008 9:05:19 AM PDT}
- INFO: Beginning work on BTN3A1... {April 9, 2008 9:20:10 AM PDT}
- REDIRECT: Protein Redirected to: BTN3A1 {April 9, 2008 9:21:37 AM PDT}
- CREATED: Created new protein page: BTN3A1 {April 9, 2008 9:21:41 AM PDT}
- INFO: Beginning work on CD300A... {April 9, 2008 9:29:55 AM PDT}
- REDIRECT: Protein Redirected to: CD300A {April 9, 2008 9:30:43 AM PDT}
- CREATED: Created new protein page: CD300A {April 9, 2008 9:30:48 AM PDT}
- INFO: Beginning work on CHD2... {April 9, 2008 9:04:07 AM PDT}
- REDIRECT: Protein Redirected to: CHD2 {April 9, 2008 9:04:40 AM PDT}
- CREATED: Created new protein page: CHD2 {April 9, 2008 9:04:46 AM PDT}
- INFO: Beginning work on DDX52... {April 9, 2008 9:16:45 AM PDT}
- REDIRECT: Protein Redirected to: DDX52 {April 9, 2008 9:18:05 AM PDT}
- CREATED: Created new protein page: DDX52 {April 9, 2008 9:18:09 AM PDT}
- INFO: Beginning work on HIBADH... {April 9, 2008 9:19:17 AM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein HIBADH image.jpg {April 9, 2008 9:19:58 AM PDT}
- REDIRECT: Protein Redirected to: HIBADH {April 9, 2008 9:20:05 AM PDT}
- CREATED: Created new protein page: HIBADH {April 9, 2008 9:20:10 AM PDT}
- INFO: Beginning work on KDELR3... {April 9, 2008 9:06:33 AM PDT}
- REDIRECT: Protein Redirected to: KDELR3 {April 9, 2008 9:08:09 AM PDT}
- CREATED: Created new protein page: KDELR3 {April 9, 2008 9:08:15 AM PDT}
- INFO: Beginning work on LZTS1... {April 9, 2008 9:24:06 AM PDT}
- REDIRECT: Protein Redirected to: LZTS1 {April 9, 2008 9:26:08 AM PDT}
- CREATED: Created new protein page: LZTS1 {April 9, 2008 9:26:12 AM PDT}
- INFO: Beginning work on NUDT5... {April 9, 2008 9:23:39 AM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein NUDT5 image.jpg {April 9, 2008 9:23:53 AM PDT}
- REDIRECT: Protein Redirected to: NUDT5 {April 9, 2008 9:24:00 AM PDT}
- CREATED: Created new protein page: NUDT5 {April 9, 2008 9:24:06 AM PDT}
- INFO: Beginning work on NXPH3... {April 9, 2008 9:28:47 AM PDT}
- REDIRECT: Protein Redirected to: NXPH3 {April 9, 2008 9:29:14 AM PDT}
- CREATED: Created new protein page: NXPH3 {April 9, 2008 9:29:22 AM PDT}
- INFO: Beginning work on PNRC1... {April 9, 2008 9:05:19 AM PDT}
- REDIRECT: Protein Redirected to: PNRC1 {April 9, 2008 9:05:46 AM PDT}
- CREATED: Created new protein page: PNRC1 {April 9, 2008 9:05:50 AM PDT}
- INFO: Beginning work on POLG2... {April 9, 2008 9:27:52 AM PDT}
- REDIRECT: Protein Redirected to: POLG2 {April 9, 2008 9:28:06 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {April 9, 2008 9:28:08 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {April 9, 2008 9:28:08 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {April 9, 2008 9:28:08 AM PDT}
- UPDATED: Updated protein page: POLG2 {April 9, 2008 9:28:10 AM PDT}
- INFO: Beginning work on PXMP4... {April 9, 2008 9:29:22 AM PDT}
- REDIRECT: Protein Redirected to: PXMP4 {April 9, 2008 9:29:50 AM PDT}
- CREATED: Created new protein page: PXMP4 {April 9, 2008 9:29:55 AM PDT}
- INFO: Beginning work on RAB31... {April 9, 2008 9:14:48 AM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein RAB31 image.jpg {April 9, 2008 9:16:28 AM PDT}
- REDIRECT: Protein Redirected to: RAB31 {April 9, 2008 9:16:35 AM PDT}
- CREATED: Created new protein page: RAB31 {April 9, 2008 9:16:44 AM PDT}
- INFO: Beginning work on RAB35... {April 9, 2008 9:08:15 AM PDT}
- REDIRECT: Protein Redirected to: RAB35 {April 9, 2008 9:09:26 AM PDT}
- CREATED: Created new protein page: RAB35 {April 9, 2008 9:09:33 AM PDT}
- INFO: Beginning work on RBPMS... {April 9, 2008 9:13:36 AM PDT}
- REDIRECT: Protein Redirected to: RBPMS {April 9, 2008 9:14:40 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {April 9, 2008 9:14:44 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {April 9, 2008 9:14:44 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {April 9, 2008 9:14:44 AM PDT}
- UPDATED: Updated protein page: RBPMS {April 9, 2008 9:14:48 AM PDT}
- INFO: Beginning work on RCBTB2... {April 9, 2008 9:03:28 AM PDT}
- REDIRECT: Protein Redirected to: RCBTB2 {April 9, 2008 9:03:58 AM PDT}
- CREATED: Created new protein page: RCBTB2 {April 9, 2008 9:04:06 AM PDT}
- INFO: Beginning work on RNF139... {April 9, 2008 9:28:10 AM PDT}
- REDIRECT: Protein Redirected to: RNF139 {April 9, 2008 9:28:41 AM PDT}
- CREATED: Created new protein page: RNF139 {April 9, 2008 9:28:47 AM PDT}
- INFO: Beginning work on SLC27A5... {April 9, 2008 9:05:50 AM PDT}
- REDIRECT: Protein Redirected to: SLC27A5 {April 9, 2008 9:06:28 AM PDT}
- CREATED: Created new protein page: SLC27A5 {April 9, 2008 9:06:33 AM PDT}
- INFO: Beginning work on TDRKH... {April 9, 2008 9:09:33 AM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein TDRKH image.jpg {April 9, 2008 9:13:15 AM PDT}
- REDIRECT: Protein Redirected to: TDRKH {April 9, 2008 9:13:22 AM PDT}
- CREATED: Created new protein page: TDRKH {April 9, 2008 9:13:36 AM PDT}
- INFO: Beginning work on WBP4... {April 9, 2008 9:26:12 AM PDT}
- UPLOAD: Added new Image to wiki: File:PBB Protein WBP4 image.jpg {April 9, 2008 9:27:13 AM PDT}
- REDIRECT: Protein Redirected to: WBP4 {April 9, 2008 9:27:20 AM PDT}
- CREATED: Created new protein page: WBP4 {April 9, 2008 9:27:23 AM PDT}
- INFO: Beginning work on WDR45... {April 9, 2008 9:21:41 AM PDT}
- REDIRECT: Protein Redirected to: WDR45 {April 9, 2008 9:23:34 AM PDT}
- CREATED: Created new protein page: WDR45 {April 9, 2008 9:23:38 AM PDT}
end log.