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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Neuronatin
| HGNCid = 7860
| Symbol = NNAT
| AltSymbols =; MGC1439; Peg5
| OMIM = 603106
| ECnumber =
| Homologene = 36176
| MGIid = 104716
| GeneAtlas_image1 = PBB_GE_NNAT_204239_s_at_tn.png
| Function = {{GNF_GO|id=GO:0015457 |text = auxiliary transport protein activity}}
| Component =
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0009249 |text = protein lipoylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4826
| Hs_Ensembl = ENSG00000053438
| Hs_RefseqProtein = NP_005377
| Hs_RefseqmRNA = NM_005386
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 35583021
| Hs_GenLoc_end = 35585502
| Hs_Uniprot = Q16517
| Mm_EntrezGene = 18111
| Mm_Ensembl = ENSMUSG00000067786
| Mm_RefseqmRNA = NM_010923
| Mm_RefseqProtein = NP_035053
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 157251551
| Mm_GenLoc_end = 157253958
| Mm_Uniprot = Q548Q0
}}
}}
'''Neuronatin''', also known as '''NNAT''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NNAT neuronatin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4826| accessdate = }}</ref>
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{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a proteolipid that may be involved in the regulation of ion channels during brain development. The encoded protein may also play a role in forming and maintaining the structure of the nervous system. This gene is found within an intron of the BLCAP gene, but on the opposite strand. This gene is imprinted and is expressed only from the paternal allele, while BLCAP is not imprinted. Two transcript variants encoding two different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: NNAT neuronatin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4826| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Dou D, Joseph R |title=Structure and organization of the human neuronatin gene. |journal=Genomics |volume=33 |issue= 2 |pages= 292-7 |year= 1997 |pmid= 8660979 |doi= 10.1006/geno.1996.0195 }}
*{{cite journal | author=Dou D, Joseph R |title=Cloning of human neuronatin gene and its localization to chromosome-20q 11.2-12: the deduced protein is a novel "proteolipid'. |journal=Brain Res. |volume=723 |issue= 1-2 |pages= 8-22 |year= 1996 |pmid= 8813377 |doi= }}
*{{cite journal | author=Usui H, Morii K, Tanaka R, ''et al.'' |title=cDNA cloning and mRNA expression analysis of the human neuronatin. High level expression in human pituitary gland and pituitary adenomas. |journal=J. Mol. Neurosci. |volume=9 |issue= 1 |pages= 55-60 |year= 1998 |pmid= 9356927 |doi= }}
*{{cite journal | author=John RM, Aparicio SA, Ainscough JF, ''et al.'' |title=Imprinted expression of neuronatin from modified BAC transgenes reveals regulation by distinct and distant enhancers. |journal=Dev. Biol. |volume=236 |issue= 2 |pages= 387-99 |year= 2001 |pmid= 11476579 |doi= 10.1006/dbio.2001.0327 }}
*{{cite journal | author=Evans HK, Wylie AA, Murphy SK, Jirtle RL |title=The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2. |journal=Genomics |volume=77 |issue= 1-2 |pages= 99-104 |year= 2001 |pmid= 11543638 |doi= 10.1006/geno.2001.6612 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Kuerbitz SJ, Pahys J, Wilson A, ''et al.'' |title=Hypermethylation of the imprinted NNAT locus occurs frequently in pediatric acute leukemia. |journal=Carcinogenesis |volume=23 |issue= 4 |pages= 559-64 |year= 2002 |pmid= 11960906 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Su ZZ, Kang DC, Chen Y, ''et al.'' |title=Identification of gene products suppressed by human immunodeficiency virus type 1 infection or gp120 exposure of primary human astrocytes by rapid subtraction hybridization. |journal=J. Neurovirol. |volume=9 |issue= 3 |pages= 372-89 |year= 2003 |pmid= 12775420 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Uchihara T, Okubo C, Tanaka R, ''et al.'' |title=Neuronatin expression and its clinicopathological significance in pulmonary non-small cell carcinoma. |journal=Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer |volume=2 |issue= 9 |pages= 796-801 |year= 2007 |pmid= 17805055 |doi= 10.1097/JTO.0b013e318145af5e }}
}}
{{refend}}
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